The importance of Propolis is its capacity to be complementary, enhancing the effects of antibiotics and other medication, while at the same time healing damaged tissue.
Protective effects of Chineseand Brazilian propolis treatment against hepatorenal lesion in diabetic rats
College of AnimalSciences, Zhejiang University; Hum Exp Toxicol Sept 2011 vol. 30
Protective effects of Chineseand Brazilian propolis treatment against hepatorenal lesion in diabetic rats
College of AnimalSciences, Zhejiang University; Hum Exp Toxicol Sept 2011 vol. 30
Abstract
Diabetes mellitus promoted an overproduction of freeradicals and an increased incidence of both diabetic nephropathy and liverdisease. In this report, we evaluated the effects of Chinese and Brazilianpropolis on streptozotocin-induced hepatorenal injury in rats.
The results demonstrated that Chinese propolis-treatedrats had a 7.4% reduction in the glycated hemoglobin (HbAlc) level comparedwith untreated diabetic rats. Additionally, Chinese propolis induced anincrease in the serum superoxide dismutase (SOD) level significantly whileBrazilian propolis raised serum SOD and reduced level of malonaldehyde (MDA)and nitric synthetase (NOS). Of the measurable decrease in serum alanine transaminase(ALT), aspartate transaminase (AST) and microalbuminuria demonstrated thepropolis-mediated improvement of hepatorenal function, which was furtherconfirmed by histological examination.
We also observed that Chinese and Brazilian propolisincreased hepatorenal glutathione peroxidase (GSH-px) level and inhibited MDAproduction significantly. These results suggested that propolis may preventhepatorenal injury by inhibiting lipid peroxidation and enhancing theactivities of antioxidant enzymes.
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